Alzheimer disease fibroblasts are hypersensitive to the lethal effects of a DNA-damaging chemical.

doi:10.1016/0027-5107(86)90121-1

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Article

Alzheimer disease fibroblasts are hypersensitive to the lethal effects of a DNA-damaging chemical.

Mutation research - 1 Jan 2000

Scudiero D A, Polinsky R J, Brumback R A, Tarone R E, Nee L E, Robbins J H

Abstract excerpt

A group of fibroblast lines from three patients with the sporadic form of Alzheimer disease (AD) showed a small but statistically significant hypersensitivity to the lethal effects of the DNA-damaging chemical N-methyl-N'-nitro-nitrosoguanidine (MNNG) when compared with lines from eight normal co...

Topics

Alzheimer Disease
Cell Survival
Cells, Cultured
DNA Repair
Female
Humans
Male
Methylnitronitrosoguanidine
Muscular Atrophy
Mutation

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