Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild type but not mutant APP is involved in protective adaptive responses against oxidants.

Amino acids - 1 Jun 2010

Cenini Giovanna, Maccarinelli Giuseppina, Lanni Cristina, Bonini Sara Anna, Ferrari-Toninelli Giulia, Govoni Stefano, Racchi Marco, Butterfield David Allan, Memo Maurizio, Uberti Daniela

Abstract excerpt

This study points out different behaviour between HEK cells overexpressing wild-type or mutant APP when exposed to oxidative insult. Although apparently both APPwt and APPmut overexpression conferred resistance to oxidative insult, some differences in terms of degree of protection was observed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blotting, Western

Share to Cells, Cultured

Share to Oxidants

Share to Oxidation-Reduction

Share to Oxidative Stress

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 20063202
DOI: 10.1007/s00726-009-0438-1

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20063202-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild type but not mutant APP is involved in protective adaptive responses against oxidants.PMID 20063202Read ↗

Increased apoptotic cell death in sporadic and genetic Alzheimer's disease.Semantic proximity Read ↗

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.Semantic proximity Read ↗

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway.Semantic proximity Read ↗

Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation.Semantic proximity Read ↗

Neuroprotective effects of PrxI over‐expression in an in vitro human Alzheimer's disease modelSemantic proximity Read ↗

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death.Semantic proximity Read ↗

[PC12 cells transfected with human mutant gene causing one of Alzheimer's disease forms have a high sensitivity to oxidative stress].Semantic proximity Read ↗

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.Semantic proximity Read ↗

Differential alterations in antioxidant capacity in cells from Alzheimer patients.Semantic proximity Read ↗

The effect of oxidative stress on amyloid precursor protein processing in cells engaged in beta-amyloidosis is related to apolipoprotein E genotype.Semantic proximity Read ↗

Increased antioxidant enzyme activity in amyloid beta protein-resistant cellsSemantic proximity Read ↗

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.