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Article

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.

Neurobiology of disease - 1 Apr 2001

Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Müller W E

Abstract excerpt

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell death. Interestingly, enhanced vulnerability to cell death has also been demonstrated for peripheral lymphocytes from AD patients. We now report that lymphocytes...

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Identifiers

PMID: 11300728
DOI: 10.1006/nbdi.2000.0378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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