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Article

Bayesian analysis of mutational spectra.

Genetics - 1 Nov 2000

Dunson D B, Tindall K R

Abstract excerpt

Studies that examine both the frequency of gene mutation and the pattern or spectrum of mutational changes can be used to identify chemical mutagens and to explore the molecular mechanisms of mutagenesis. In this article, we propose a Bayesian hierarchical modeling approach for the analysis of mutational spectra. We assume that the total number of independent mutations and the numbers of mutations falling into...

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Identifiers

PMID: 11063712
DOI: 10.1093/genetics/156.3.1411
PMCID: PMC1461324

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