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Determination of Mutational Spectra Induced by Environmental Toxicants in Complex Human Cell Populations.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Gealy Robert, Keohavong Phouthone

Abstract excerpt

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed in the environment and have potent mutagenic and carcinogenic activities. Studies of mutations induced by these compounds in human cells can help acquire an understanding of their mutagenic pathways. In this chapter, independent cultures of a human cell line expressing cytochrome P450 CYP1A1 (cell line MCL-5) were treated with benzo(a)pyrene (BaP) or...

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PMID: 31989563
DOI: 10.1007/978-1-0716-0223-2_17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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