Article
Comparison of induced and cancer-associated mutational spectra using multivariate data analysis.
Carcinogenesis - 1 Apr 2008
Lewis P D, Manshian B, Routledge M N, Scott G B, Burns P A
Abstract excerpt
One of the most useful tools for investigating the aetiopathology of cancer is the mutation spectrum, which comprises the type and distribution of mutations within a gene sequence. Many studies have generated mutagen-induced spectra using in vitro or in vivo model systems in an attempt to find correlations with those observed in cancer-associated genes such as the TP53 tumour suppressor gene. Consequently,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.