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Article

Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance.

Journal of molecular biology - 27 Jul 2001

Nordgren S, Slagter-Jäger J G, Wagner G H

Abstract excerpt

Antisense RNAs interact with their complementary target RNAs as folded structures. The formation of early binding intermediates is the most important step in determining the overall rates of stable complex formation in vitro and the efficiency of control in vivo. In the case of CopA and CopT (antisense/target RNA pair of plasmid R1), recent studies have identified a four-way junction structure as the major...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11502000
DOI: 10.1006/jmbi.2001.4802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance.PMID 11502000Read ↗

Progression of a loop-loop complex to a four-way junction is crucial for the activity of a regulatory antisense RNA.Semantic proximity Read ↗

Bulged residues promote the progression of a loop-loop interaction to a stable and inhibitory antisense-target RNA complex.Semantic proximity Read ↗

An antisense/target RNA duplex or a strong intramolecular RNA structure 5' of a translation initiation signal blocks ribosome binding: the case of plasmid R1.Semantic proximity Read ↗

Control of replication of plasmid R1: the duplex between the antisense RNA, CopA, and its target, CopT, is processed specifically in vivo and in vitro by RNase III.Semantic proximity Read ↗

Thermodynamic and kinetic analysis of an RNA kissing interaction and its resolution into an extended duplex.Semantic proximity Read ↗

Probing the kinetics of formation of the bacteriophage MS2 translational operator complex: identification of a protein conformer unable to bind RNA.Semantic proximity Read ↗

Control of replication of plasmid R1: the intergenic region between copA and repA modulates the level of expression of repA.Semantic proximity Read ↗

Regulation of replication of plasmid R1: an analysis of the intergenic region between copA and repA.Semantic proximity Read ↗

Regulation of plasmid R1 replication: PcnB and RNase E expedite the decay of the antisense RNA, CopA.Semantic proximity Read ↗

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