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Article

Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile105Val polymorphism.

Cancer research - 15 Oct 2000

Sweeney C, McClure G Y, Fares M Y, Stone A, Coles B F, Thompson P A, Korourian S, Hutchins L F, Kadlubar F F, Ambrosone C B

Abstract excerpt

A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to GSTP1 genotype among women (n = 240) treated for breast cancer. Women with the low-activity...

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Source

Identifiers

PMID: 11059750

Genes

GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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