Article
Polymorphic variation in GSTP1 modulates outcome following therapy for multiple myeloma.
Blood - 1 Oct 2003
Dasgupta Ranjit K, Adamson Peter J, Davies Faith E, Rollinson Sara, Roddam Philippa L, Ashcroft A John, Dring Ann M, Fenton James A L, Child J Anthony, Allan James M, Morgan Gareth J
Abstract excerpt
Glutathione S-transferase P1 (GSTP1) is a phase 2 drug metabolism enzyme involved in the metabolism and detoxification of a range of chemotherapeutic agents. A single nucleotide polymorphism (Ile105Val) results in a variant enzyme with lower thermal stability and altered catalytic activity. We hypothesized that patients with the less stable variant have a decreased ability to detoxify chemotherapeutic substrates,...
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