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Article

The GSTP1 105Val allele increases breast cancer risk and aggressiveness but enhances response to cyclophosphamide chemotherapy in North China.

PloS one - 1 Jan 2013

Ge Jie, Tian Ai-Xian, Wang Qing-Shan, Kong Peng-Zhou, Yu Yue, Li Xiao-Qing, Cao Xu-Chen, Feng Yu-Mei

Abstract excerpt

The glutathione-S-transferase (GST) family contributes to the inactivation of various toxic compounds formed as secondary metabolites during oxidative stress. GSTP1 accounts for the majority of the GST family enzymatic activity, and the activity of GSTP1 enzyme can be altered by the presence of the Ile105Val polymorphism. In this study, we examined the polymorphic frequency of GSTP1 Ile105Val genotype in 920...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23826324
DOI: 10.1371/journal.pone.0067589
PMCID: PMC3691318

Genes

GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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The GSTP1 105Val allele increases breast cancer risk and aggressiveness but enhances response to cyclophosphamide chemotherapy in North China.PMID 23826324Read ↗

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Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer.Semantic proximity Read ↗

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