Article
Genetic variants in the glutathione S-transferase genes and survival in colorectal cancer patients after chemotherapy and differences according to treatment with oxaliplatin.
Pharmacogenetics and genomics - 1 Jul 2014
Kap Elisabeth J, Richter Swantje, Rudolph Anja, Jansen Lina, Ulrich Alexis, Hoffmeister Michael, Ulrich Cornelia M, Brenner Hermann, Chang-Claude Jenny
Abstract excerpt
INTRODUCTION: The glutathione S-transferase (GST) enzymes are involved in the detoxification of a range of carcinogenic compounds as well as chemotherapeutic agents. Therefore, genetic variants in the GST genes could influence survival in patients with colorectal cancer (CRC). Results from previous studies have been inconsistent and therefore we investigated the association between the GSTP1 ile105val...
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