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Article

Association between a glutathione S-transferase A1 promoter polymorphism and survival after breast cancer treatment.

International journal of cancer - 1 Mar 2003

Sweeney Carol, Ambrosone Christine B, Joseph Lija, Stone Angie, Hutchins Laura F, Kadlubar Fred F, Coles Brian F

Abstract excerpt

Glutathione S-transferase (GST) enzymes detoxify chemotherapeutic drugs, and several studies have reported differences in survival for cancer patients who have variant genotypes for GSTP1, GSTM1 or GSTT1 enzymes. A recently described polymorphism alters hepatic expression of GSTA1, a GST with high activity in glutathione conjugation of metabolites of cyclophosphamide (CP). To consider the possible influence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12516103
DOI: 10.1002/ijc.10896

Genes

GSTA1
GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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