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Article

Increased frequencies of gene and chromosome mutations after X-irradiation in mouse embryonal carcinoma cells transfected with the bcl-2 gene.

Japanese journal of cancer research : Gann - 1 Oct 2000

Taga M, Shiraishi K, Shimura T, Uematsu N, Oshimura M, Niwa O

Abstract excerpt

Preimplantation stage mouse embryos are known to be highly sensitive to the killing effect of DNA-damaging agents such as radiation. Interestingly, however, this stage of development is well protected from radiation induction of malformation and carcinogenesis in postnatal life. In recent years, it has become clear that the stem cells of preimplantation stage embryos undergo extensive apoptosis after DNA damage....

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Identifiers

PMID: 11050469
DOI: 10.1111/j.1349-7006.2000.tb00876.x
PMCID: PMC5926261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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