Article
Radiation sensitivity of the gastrula-stage embryo: Chromosome aberrations and mutation induction in lacZ transgenic mice: The roles of DNA double-strand break repair systems.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Oct 2015
Jacquet Paul, van Buul Paul, van Duijn-Goedhart Annemarie, Reynaud Karine, Buset Jasmine, Neefs Mieke, Michaux Arlette, Monsieurs Pieter, de Boer Peter, Baatout Sarah
Abstract excerpt
At the gastrula phase of development, just after the onset of implantation, the embryo proper is characterized by extremely rapid cell proliferation. The importance of DNA repair is illustrated by embryonic lethality at this stage after ablation of the genes involved. Insight into mutation induction is called for by the fact that women often do not realize they are pregnant, shortly after implantation, a...
Topics
- Animals
- Cell Proliferation
- Chromosome Aberrations
- DNA Breaks, Double-Stranded
- DNA Mutational Analysis
- DNA Repair
- Female
- Gastrula
- Gene Deletion
- Lac Operon
- Male
- Mice
- Mice, Inbred BALB C