Article
The bcl-2 gene status of human head and neck cancer cell lines.
Acta oto-laryngologica. Supplementum - 1 Jan 1997
Salo A, Servomaa K, Kiuru A, Pulkkinen J, Grénman R, Pekkola-Heino K, Rytömaa T
Abstract excerpt
The bcl-2 oncogene was originally found in the translocation in a pre-B cell acute lymphocytic leukemia cell line. Since then a high expression of Bcl-2 has been found in many types of cancer. The bcl-2 gene encodes an intracellular membrane-associated protein. Overexpression of bcl-2 inhibits apoptosis induced by many drugs and radiation. In this study the bcl-2 gene status of 9 human head and neck squamous cell...
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