The bcl-2 gene status of human head and neck cancer cell lines.

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Article

The bcl-2 gene status of human head and neck cancer cell lines.

Acta oto-laryngologica. Supplementum - 1 Jan 1997

Salo A, Servomaa K, Kiuru A, Pulkkinen J, Grénman R, Pekkola-Heino K, Rytömaa T

Abstract excerpt

The bcl-2 oncogene was originally found in the translocation in a pre-B cell acute lymphocytic leukemia cell line. Since then a high expression of Bcl-2 has been found in many types of cancer. The bcl-2 gene encodes an intracellular membrane-associated protein. Overexpression of bcl-2 inhibits ap...

Topics

Apoptosis
Carcinoma, Squamous Cell
DNA, Neoplasm
Genes, bcl-2
Genes, p53
Head and Neck Neoplasms
Heterozygote
Humans
Mutation
Point Mutation
Proto-Oncogene Proteins c-bcl-2
RNA, Messenger
Radiation Tolerance
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9288319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9288319-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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