Article
The high susceptibility of heterozygous p53(+/-) mice to malformation after foetal irradiation is related to sub-competent apoptosis.
International journal of radiation biology - 1 Oct 1998
Nomoto S, Ootsuyama A, Shioyama Y, Katsuki M, Kondo S, Norimura T
Abstract excerpt
PURPOSE: To investigate the relationship between the incidence of radiation-induced malformations and the extent of p53-dependent apoptosis. MATERIALS AND METHODS: Wild-type p53(+ / +) and heterozygous p53(+ / -) mice were exposed to X-rays at the mid-gestational period. The incidence of anomalie...
Topics
- Alleles
- Animals
- Apoptosis
- Dose-Response Relationship, Radiation
- Fetal Death
- Fetus
- Genes, p53
- Gestational Age
- Heterozygote
- Kinetics
- Mice
- Nuclear Proteins
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- RNA, Messenger
- Radiation Tolerance
- Tumor Suppressor Protein p53
- X-Rays