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Article

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells.

Oncogene - 25 Feb 1999

Corbet S W, Clarke A R, Gledhill S, Wyllie A H

Abstract excerpt

The hypothesis that p53 deficiency enhances the survival of DNA-damage bearing cells was investigated in wild-type and p53 mutant embryonic stem (ES) cells. Following UV-C irradiation, p53 is rapidly induced in wild-type cells and p53-dependent apoptosis follows within 8 h, resulting in the death of the majority of cells within 36 h. Increasing doses of UV-irradiation resulted in enhanced clonogenic survival of...

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Source

Identifiers

PMID: 10102623
DOI: 10.1038/sj.onc.1202436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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