Article
The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation.
Molecular and cellular biology - 1 Nov 2000
Jenab-Wolcott J, Rodriguez-Correa D, Reitmair A H, Mak T, Rosenberg N
Abstract excerpt
Defects in DNA mismatch repair predispose cells to the development of several types of malignant disease. The absence of Msh2 or Mlh1, two key molecules that mediate mismatch repair in eukaryotic cells, increases the frequency of mutation and also alters the response of some cells to apoptosis and cell cycle arrest. To understand the way these changes contribute to cancer predisposition, we examined the effects...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.