Article
Absence of p53 complements defects in Abelson murine leukemia virus signaling.
Journal of virology - 1 Jun 2003
Unnikrishnan Indira, Rosenberg Naomi
Abstract excerpt
The v-Abl protein encoded by Abelson murine leukemia virus (Ab-MLV) induces transformation of pre-B cells via a two-stage process. An initial proliferative phase during which cells with limited tumorigenic potential expand is followed by a crisis period marked by high levels of apoptosis and erratic growth. Transformants that survive this phase emerge as fully malignant cells and usually contain mutations that...
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