Article
Varying intertrial interval reveals temporally defined memory deficits and enhancements in NTAN1-deficient mice.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Jan 2000
Balogh S A, Kwon Y T, Denenberg V H
Abstract excerpt
The N-end rule is one ubiquitin-proteolytic pathway that relates the in vivo half-life of a protein to the identity of its N-terminal residue. NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1. An N-terminal arginine-bearing substrate protein is recognized, ubiquitylated by UBR1/E3alpha, and subsequently degraded by 26S proteasomes. Previous research showed that...
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