Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Apr 2008

Bannerman David M, Niewoehner Burkhard, Lyon Louisa, Romberg Carola, Schmitt Wolfram B, Taylor Amy, Sanderson David J, Cottam James, Sprengel Rolf, Seeburg Peter H, Köhr Georg, Rawlins John N P

Abstract excerpt

NMDA receptors (NMDARs) containing NR2A (epsilon1) subunits are key contributors to hippocampal long-term potentiation (LTP) induction in adult animals and have therefore been widely implicated in hippocampus-dependent spatial learning. Here we show that mice lacking the NR2A subunit or its C-terminal intracellular domain exhibit impaired spatial working memory (SWM) but normal spatial reference memory (SRM)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Psychological

Share to Exploratory Behavior

Share to Maze Learning

Share to Memory, Short-Term

Share to Receptors, N-Methyl-D-Aspartate

Share to Space Perception

Source

Open in PubMed Open full text

Identifiers

PMID: 18385321
DOI: 10.1523/JNEUROSCI.3639-07.2008
PMCID: PMC6671075

Genes

SRM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory.PMID 18385321Read ↗

Spatial memory dissociations in mice lacking GluR1.Semantic proximity Read ↗

Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks.Semantic proximity Read ↗

Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation.Semantic proximity Read ↗

Plasticity, hippocampal place cells, and cognitive maps.Semantic proximity Read ↗

NMDA receptors are not required for pattern completion during associative memory recall.Semantic proximity Read ↗

Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.Semantic proximity Read ↗

Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly.Semantic proximity Read ↗

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit.Semantic proximity Read ↗

Working memory deficits in retinoid X receptor gamma-deficient mice.Semantic proximity Read ↗

Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning.Semantic proximity Read ↗

Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic MemorySemantic proximity Read ↗

Intermediate CA1 is Required for Object-in-Place Recognition Memory in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.