Article
Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila.
Science (New York, N.Y.) - 11 Aug 2006
Didelot Gérard, Molinari Florence, Tchénio Paul, Comas Daniel, Milhiet Elodie, Munnich Arnold, Colleaux Laurence, Preat Thomas
Abstract excerpt
Mutations in the human neurotrypsin gene are associated with autosomal recessive mental retardation. To further understand the pathophysiological consequences of the lack of this serine protease, we studied Tequila (Teq), the Drosophila neurotrypsin ortholog, using associative memory as a behavioral readout. We found that teq inactivation resulted in a long-term memory (LTM)-specific defect. After LTM...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Conditioning, Classical
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression
- Gene Expression Regulation
- Humans
- Learning
- Memory
- Mifepristone
- Models, Animal