Article
Behavioral characterization of mice lacking the ubiquitin ligase UBR1 of the N-end rule pathway.
Genes, brain, and behavior - 1 Nov 2002
Balogh S A, McDowell C S, Denenberg V H
Abstract excerpt
The N-end rule pathway, a subset of the ubiquitin pathway, relates the in vivo half-life of a protein to the identity of its N-terminal residue. Mice lacking NTAN1, a component of the N-end rule pathway, showed altered learning and memory, and socially conditioned behavioral alteration (Balogh, Kwon, & Denenberg 1999, 2000; Kwon, Balogh et al. 2000; Balogh et al. 2001). Mice lacking UBR1 (E3alpha), one of at...
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