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Article

Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo.

Molecular and cellular biology - 1 Jan 2010

Meury Thomas, Akhouayri Omar, Jafarov Toghrul, Mandic Vice, St-Arnaud René

Abstract excerpt

Nascent-polypeptide-associated complex and coactivator alpha (alpha NAC) is a protein shuttling between the nucleus and the cytoplasm. Upon phosphorylation at residue serine 43 by integrin-linked kinase, alpha NAC is translocated to the nuclei of osteoblasts, where it acts as an AP-1 coactivator to increase osteocalcin gene transcription. To determine the physiological role of nuclear alpha NAC, we engineered a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19884350
DOI: 10.1128/MCB.00378-09
PMCID: PMC2798287

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SOST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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