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Article

Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection.

Scientific reports - 24 Sept 2021

Clarke Jenny, Baltazar Murielle, Alsahag Mansoor, Panagiotou Stavros, Pouget Marion, Paxton William A, Pollakis Georgios, Everett Dean, French Neil, Kadioglu Aras

Abstract excerpt

Group A Streptoccocus (GAS) is among the most diverse of all human pathogens, responsible for a range of clinical manifestations, from mild superficial infections such as pharyngitis to serious invasive infections such as necrotising fasciitis and sepsis. The drivers of these different disease phenotypes are not known. The GAS cholesterol-dependent cytolysin, Streptolysin O (SLO), has well established cell and...

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Identifiers

PMID: 34561464
DOI: 10.1038/s41598-021-97866-4
PMCID: PMC8463576

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