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Article

Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein.

The EMBO journal - 16 Oct 2000

Ginger R S, Dalton E C, Ryves W J, Fukuzawa M, Williams J G, Harwood A J

Abstract excerpt

Extracellular cAMP stimulates the rapid tyrosine phosphorylation and nuclear translocation of the DICTYOSTELIUM: STAT protein Dd-STATa. Here we show that it also induces serine phosphorylation by GskA, a homologue of glycogen synthase kinase-3 (GSK-3). Tyrosine phosphorylation occurs within 10 s of stimulation, whereas serine phosphorylation takes 5 min, matching the kinetics observed for the cAMP regulation of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11032815
DOI: 10.1093/emboj/19.20.5483
PMCID: PMC314011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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