Article
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes.
American journal of human genetics - 1 Nov 2000
Ghosh S, Watanabe R M, Valle T T, Hauser E R, Magnuson V L, Langefeld C D, Ally D S, Mohlke K L, Silander K, Kohtamäki K, Chines P, Balow J, Birznieks G, Chang J, Eldridge W, Erdos M R, Karanjawala Z E, Knapp J I, Kudelko K, Martin C, Morales-Mena A, Musick A, Musick T, Pfahl C, Porter R, Rayman J B
Abstract excerpt
We performed a genome scan at an average resolution of 8 cM in 719 Finnish sib pairs with type 2 diabetes. Our strongest results are for chromosome 20, where we observe a weighted maximum LOD score (MLS) of 2.15 at map position 69.5 cM from pter and secondary weighted LOD-score peaks of 2.04 at 56.5 cM and 1.99 at 17.5 cM. Our next largest MLS is for chromosome 11 (MLS = 1.75 at 84.0 cM), followed by chromosomes...
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