Article
A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland.
BMC genetics - 19 Dec 2007
Qiao Qing, Osterholm Anne-May, He Bing, Pitkäniemi Janne, Cordell Heather J, Sarti Cinzia, Kinnunen Leena, Tuomilehto-Wolf Eva, Tryggvason Karl, Tuomilehto Jaakko
Abstract excerpt
BACKGROUND: A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying...
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