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Article

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.

Diabetes - 1 Apr 2004

Silander Kaisa, Mohlke Karen L, Scott Laura J, Peck Erin C, Hollstein Pablo, Skol Andrew D, Jackson Anne U, Deloukas Panagiotis, Hunt Sarah, Stavrides George, Chines Peter S, Erdos Michael R, Narisu Narisu, Conneely Karen N, Li Chun, Fingerlin Tasha E, Dhanjal Sharanjeet K, Valle Timo T, Bergman Richard N, Tuomilehto Jaakko, Watanabe Richard M, Boehnke Michael, Collins Francis S

Abstract excerpt

The Finland-United States Investigation Of NIDDM Genetics (FUSION) study aims to identify genetic variants that predispose to type 2 diabetes by studying affected sibling pair families from Finland. Chromosome 20 showed our strongest initial evidence for linkage. It currently has a maximum logari...

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Source

Identifiers

PMID: 15047633
DOI: 10.2337/diabetes.53.4.1141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15047633-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.PMID 15047633Read ↗

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.Semantic proximity Read ↗

Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.Semantic proximity Read ↗

The role of HNF4A variants in the risk of type 2 diabetes.Semantic proximity Read ↗

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.Semantic proximity Read ↗

Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.Semantic proximity Read ↗

Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish.Semantic proximity Read ↗

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.Semantic proximity Read ↗

Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population.Semantic proximity Read ↗

Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.Semantic proximity Read ↗

Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians.Semantic proximity Read ↗

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.Semantic proximity Read ↗

A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14.Semantic proximity Read ↗

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