Article
Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 1999
Ghosh S, Watanabe R M, Hauser E R, Valle T, Magnuson V L, Erdos M R, Langefeld C D, Balow J, Ally D S, Kohtamaki K, Chines P, Birznieks G, Kaleta H S, Musick A, Te C, Tannenbaum J, Eldridge W, Shapiro S, Martin C, Witt A, So A, Chang J, Shurtleff B, Porter R, Kudelko K, Unni A, Segal L, Sharaf R, Blaschak-Harvan J, Eriksson J, Tenkula T, Vidgren G, Ehnholm C, Tuomilehto-Wolf E, Hagopian W, Buchanan T A, Tuomilehto J, Bergman R N, Collins F S, Boehnke M
Abstract excerpt
We are conducting a genome scan at an average resolution of 10 centimorgans (cM) for type 2 diabetes susceptibility genes in 716 affected sib pairs from 477 Finnish families. To date, our best evidence for linkage is on chromosome 20 with potentially separable peaks located on both the long and short arms. The unweighted multipoint maximum logarithm of odds score (MLS) was 3.08 on 20p (location, chi = 19.5 cM)...
Topics
- Adult
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Blood Glucose
- Chromosome Mapping
- Chromosomes, Human, Pair 20
- DNA-Binding Proteins
- Diabetes Mellitus, Type 2