Article
Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study.
American journal of human genetics - 1 Feb 2002
Lindgren C M, Mahtani M M, Widén E, McCarthy M I, Daly M J, Kirby A, Reeve M P, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop L C, Lander E S
Abstract excerpt
Type 2 diabetes mellitus is a heterogeneous inherited disorder characterized by chronic hyperglycemia resulting from pancreatic beta-cell dysfunction and insulin resistance. Although the pathogenic mechanisms are not fully understood, manifestation of the disease most likely requires interaction between both environmental and genetic factors. In the search for such susceptibility genes, we have performed a...
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