Article
Thiopurine S-methyltransferase genetic polymorphism in the Thai population.
British journal of clinical pharmacology - 1 Jul 2004
Srimartpirom Somrudee, Tassaneeyakul Wongwiwat, Kukongviriyapan Veerapol, Tassaneeyakul Wichittra
Abstract excerpt
AIMS: To determine the incidence of the thiopurine S-methyltransferase (TPMT) genetic polymorphism in the Thai population. METHODS: Genomic DNAs were isolated from peripheral blood leucocytes of 200 healthy Thais. The frequencies of five allelic variants of the TPMT gene, TPMT*2, *3A, *3B, *3C and *6 were determined using allele specific polymerase chain reaction (PCR) or PCR-Restriction fragment length...
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