Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased susceptibility to ischemia-induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2000

Aoki Y, Huang Z, Thomas S S, Bhide P G, Huang I, Moskowitz M A, Reeves S A

Abstract excerpt

Cell culture studies have established SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) as an important factor in growth factor and cytokine-activated signaling pathways. However, the significance of SHP2 in the mammalian central nervous system (CNS) is not known since early embryonic l...

Topics

Join the communities discussing this publication.

Brain Ischemia
Epithelium
Protein Phosphatase 2
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatases

src Homology Domains

Tissue Distribution

Source

Identifiers

PMID: 11023980
DOI: 10.1096/fj.00-0105com

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11023980-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased susceptibility to ischemia-induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2.PMID 11023980Read ↗

The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival.Semantic proximity Read ↗

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.Semantic proximity Read ↗

Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia.Semantic proximity Read ↗

Shp2 is involved in neuronal differentiation of hippocampal precursor cells.Semantic proximity Read ↗

Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells.Semantic proximity Read ↗

Generation of a conditional disruption of the <i>Tsc2</i> geneSemantic proximity Read ↗

Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia.Semantic proximity Read ↗

Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury.Semantic proximity Read ↗

Neuronal vulnerability in transgenic mice expressing an inducible dominant-negative FGF receptor.Semantic proximity Read ↗

Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons.Semantic proximity Read ↗

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growthSemantic proximity Read ↗

Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.