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Article

Increased susceptibility to ischemia-induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2000

Aoki Y, Huang Z, Thomas S S, Bhide P G, Huang I, Moskowitz M A, Reeves S A

Abstract excerpt

Cell culture studies have established SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) as an important factor in growth factor and cytokine-activated signaling pathways. However, the significance of SHP2 in the mammalian central nervous system (CNS) is not known since early embryonic lethality occurs in shp2 null mice. To bypass this embryonic lethality, transgenic animals containing a catalytically...

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PMID: 11023980
DOI: 10.1096/fj.00-0105com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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