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Article

Shp2 is involved in neuronal differentiation of hippocampal precursor cells.

Archives of pharmacal research - 1 Jun 2007

Kim Hak-Jae, Han Ah Mi, Shim Jae Hwan, Yoon Hye Hyun, Kwon Hyockman, Kwon Yunhee Kim

Abstract excerpt

HiB5 is a multipotent hippocampal stem cell line whose differentiation into cells of a neuronal phenotype is promoted by neurotrophic factors such as PDGF and brain-derived neurotrophic factor (BDNF). We examined the potential role of Src homology 2 (SH2)-containing protein tyrosine phosphatase (Shp2) in this differentiation process. We found that Shp2 became tyrosine phosphorylated following PDGF treatment....

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Platelet-Derived Growth Factor
Brain-Derived Neurotrophic Factor
Dendritic Spines
Disks Large Homolog 4 Protein
Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Protein Tyrosine Phosphatases

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Identifiers

PMID: 17679554
DOI: 10.1007/BF02977638

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Shp2 is involved in neuronal differentiation of hippocampal precursor cells.PMID 17679554Read ↗

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