Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

doi:10.1371/journal.pbio.2000080

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Article

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

PLoS biology - 1 Jan 2017

Riethmueller Steffen, Somasundaram Prasath, Ehlers Johanna C, Hung Chien-Wen, Flynn Charlotte M, Lokau Juliane, Agthe Maria, Düsterhöft Stefan, Zhu Yijue, Grötzinger Joachim, Lorenzen Inken, Koudelka Tomas, Yamamoto Kosuke, Pickhinke Ute, Wichert Rielana, Becker-Pauly Christoph, Rädisch Marisa, Albrecht Alexander, Hessefort Markus, Stahnke Dominik, Unverzagt Carlo, Rose-John Stefan, Tholey Andreas, Garbers Christoph

Abstract excerpt

Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography-mass spectrometry to identify an sIL-6R form in human serum that originates from proteolytic cleavage, map its cleavage...

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PMID: 28060820
DOI: 10.1371/journal.pbio.2000080
PMCID: PMC5218472

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