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Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins

1 May 2000

Abstract excerpt

Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Human and mouse secreted IL-18-binding proteins (IL-18BPs) have recently been described which block IL-18 activity but have no sequence similarity to membrane IL-18 receptors. Several poxvirus genes encode proteins with...

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PMID: 10769064
DOI: 10.1099/0022-1317-81-5-1223

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