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Genomic Organization and Regulation of the Human Interleukin-18 Gene. FRONTLINES

1 Dec 2000

Abstract excerpt

The human interleukin(IL)-18 is a key regulator of interferon(IFN)-gamma production and T-cell differentiation. Here we report the complete genomic structure and characterization of the 5'untranslated promoter region of the human IL-18 gene. The gene is composed of six exons and five introns, spanning approximately 19. 5kb. Promoter activity of the 5'-flanking region was investigated with a luciferase reporter...

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PMID: 11119255
DOI: 10.1046/j.1365-3083.2000.00836.x

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