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Article

Effect of intragastric application of N-methylnitrosourea in p53 knockout mice.

Molecular carcinogenesis - 1 Jun 2000

Ohgaki H, Fukuda M, Tohma Y, Huang H, Stoica G, Tatematsu M, Donehower L A

Abstract excerpt

Nullizygous p53 knockout (p53(-/-)) mice are highly susceptible to spontaneous tumorigenesis, in particular malignant lymphomas at an early age. Heterozygous p53 knockout (p53(+/-)) mice develop spontaneous tumors less frequently but may show increased susceptibility to chemical carcinogens. In this study, p53(-/-), p53(+/-), and p53 wild-type (p53(+/+)) mice were treated with N-methylnitrosourea (MNU) by gastric...

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Source

Identifiers

PMID: 10900466
DOI: 10.1002/1098-2744(200006)28:2<97::aid-mc5>3.0.co;2-o

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of intragastric application of N-methylnitrosourea in p53 knockout mice.PMID 10900466Read ↗

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