Article
Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.
Oncotarget - 20 Jul 2015
Goh Amanda M, Xue Yuezhen, Leushacke Marc, Li Ling, Wong Julin S, Chiam Poh Cheang, Rahmat Siti Aishah Binte, Mann Michael B, Mann Karen M, Barker Nick, Lozano Guillermina, Terzian Tamara, Lane David P
Abstract excerpt
The tumour suppressor p53 is regulated primarily at the protein level. In normal tissues its levels are maintained at a very low level by the action of specific E3 ligases and the ubiquitin proteosome pathway. The mutant p53 protein contributes to transformation, metastasis and drug resistance. High levels of mutant p53 can be found in tumours and the accumulation of mutant p53 has previously been reported in...
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