Article
Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation.
Genesis (New York, N.Y. : 2000) - 1 Sept 2000
Pfendler K C, Yoon J, Taborn G U, Kuehn M R, Iannaccone P M
Abstract excerpt
Mice mutant for the TGF-beta family member, nodal, lack mesoderm and die between E8.5 and E9.5. The short ear-lethal (se(l) ) mutation, a deletion that eliminates Bmp-5, causes a strikingly similar gastrulation defect. Here we analyze se(l);nodal compound mutants and find a dosage effect. Embryos homozygous for one mutation show distinct gastrulation stage defects that depend on whether they are heterozygous or...
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