Article
The efficiency of the uncleaved secretion signal in the plasminogen activator inhibitor type 2 protein can be enhanced by point mutations that increase its hydrophobicity.
The Journal of biological chemistry - 15 Aug 1991
von Heijne G, Liljeström P, Mikus P, Andersson H, Ny T
Abstract excerpt
Plasminogen-activator inhibitor type 2 (PAI-2) is a specific inhibitor of plasminogen activators that belongs to the serine protease inhibitor superfamily (SERPINS). PAI-2 exists in two molecular forms: an intracellular, non-glycosylated form and a secreted, glycosylated form. Like ovalbumin, PAI...
Topics
- Amino Acid Sequence
- Animals
- Cricetinae
- Cricetulus
- DNA
- Dogs
- Electrophoresis, Polyacrylamide Gel
- Glycosylation
- Molecular Sequence Data
- Mutation
- Plasminogen Inactivators
- Precipitin Tests
- Protein Biosynthesis
- Protein Sorting Signals
- RNA
- RNA, Messenger
- Serpins
- Transcription, Genetic