Article
The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells.
The Journal of biological chemistry - 25 May 1993
Dawson S J, Wiman B, Hamsten A, Green F, Humphries S, Henney A M
Abstract excerpt
We have detected a common (allele frequency 0.53/0.47) single base pair insertion/deletion polymorphism 675 base pairs upstream from the start of transcription of the plasminogen activator inhibitor-1 (PAI-1) gene, using the chemical cleavage mismatch analysis. "Band shift assays" suggest that th...
Topics
- Adult
- Alleles
- Base Sequence
- Binding, Competitive
- Carcinoma, Hepatocellular
- Chloramphenicol O-Acetyltransferase
- DNA Transposable Elements
- Exons
- Genotype
- Humans
- Interleukin-1
- Interleukin-6
- Liver Neoplasms
- Molecular Sequence Data
- Mutagenesis, Insertional
- Myocardial Infarction
- NF-kappa B
- Oligodeoxyribonucleotides