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Article

A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells

14 Nov 2007

Abstract excerpt

PAI-1 and PAI-2 (plasminogen-activator inibitor types 1 and 2) are inhibitors of cell surface uPA (urokinase plasminogen activator). However, tumour expression of PAI-1 and PAI-2 correlates with poor compared with good patient prognosis in breast cancer respectively. This biological divergence may be related to additional functional roles of PAI-1. For example, the inhibition of uPA by PAI-1 reveals a cryptic...

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PMID: 17696882
DOI: 10.1042/bj20070767

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