Article
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.
American journal of respiratory cell and molecular biology - 1 Oct 2011
Kelada Samir N P, Wilson Mark S, Tavarez Urraca, Kubalanza Kari, Borate Bhavesh, Whitehead Greg S, Maruoka Shuichiro, Roy Michelle G, Olive Michelle, Carpenter Danielle E, Brass David M, Wynn Thomas A, Cook Donald N, Evans Christopher M, Schwartz David A, Collins Francis S
Abstract excerpt
Asthma is etiologically and clinically heterogeneous, making the genomic basis of asthma difficult to identify. We exploited the strain-dependence of a murine model of allergic airway disease to identify different genomic responses in the lung. BALB/cJ and C57BL/6J mice were sensitized with the immunodominant allergen from the Dermatophagoides pteronyssinus species of house dust mite (Der p 1), without exogenous...
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