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Article

Inflammation influences vascular remodeling through AT2receptor expression and signaling

24 Jan 2000

Abstract excerpt

The AT(2) receptor, which exerts growth inhibitory effects in cell culture, is present scantily in the adult vasculature but is reexpressed after vascular injury. To examine the in vivo role of this receptor in vascular diseases, we developed a mouse model of vascular remodeling and compared the responses in wild-type (Agtr2(+)) and AT(2) receptor knockout (Agtr2(-)) mice. Polyethylene cuff placement on the...

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PMID: 11015577
DOI: 10.1152/physiolgenomics.2000.2.1.13

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