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Article

Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension.

American journal of respiratory and critical care medicine - 1 Oct 2015

Soon Elaine, Crosby Alexi, Southwood Mark, Yang Peiran, Tajsic Tamara, Toshner Mark, Appleby Sarah, Shanahan Catherine M, Bloch Kenneth D, Pepke-Zaba Joanna, Upton Paul, Morrell Nicholas W

Abstract excerpt

RATIONALE: Mutations in bone morphogenetic protein receptor type II (BMPR-II) underlie most cases of heritable pulmonary arterial hypertension (PAH). However, disease penetrance is only 20-30%, suggesting a requirement for additional triggers. Inflammation is emerging as a key disease-related factor in PAH, but to date there is no clear mechanism linking BMPR-II deficiency and inflammation. OBJECTIVES: To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26073741
DOI: 10.1164/rccm.201408-1509OC
PMCID: PMC4613895

Genes

PAH
BMPR2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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