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Article

Collagen inhibitory peptide R1R2 mediates vascular remodeling by decreasing inflammation and smooth muscle cell activation.

PloS one - 1 Jan 2015

Lee Ting-Hein, Sottile Jane, Chiang Hou-Yu

Abstract excerpt

The extracellular matrix (ECM) is a major constituent of the vessel wall. In addition to providing a structural scaffold, the ECM controls numerous cellular functions in both physiologic and pathologic settings. Vascular remodeling occurs after injury and is characterized by endothelial cell activation, inflammatory cell infiltration, phenotypic modulation of smooth muscle cells (SMCs), and augmented deposition...

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Identifiers

PMID: 25675397
DOI: 10.1371/journal.pone.0117356
PMCID: PMC4326127

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