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Article

The angiotensin II type 2 receptor activates flow-mediated outward remodelling through T cells-dependent interleukin-17 production.

Cardiovascular research - 1 Oct 2016

Caillon Antoine, Grenier Céline, Grimaud Linda, Vessieres Emilie, Guihot Anne-Laure, Blanchard Simon, Lelievre Eric, Chabbert Marie, Foucher Etienne D, Jeannin Pascale, Beauvillain Céline, Abraham Pierre, Loufrani Laurent, Delneste Yves, Henrion Daniel

Abstract excerpt

AIMS: The angiotensin II type 1 receptor (AT1R) through the activation of immune cells plays a key role in arterial inward remodelling and reduced blood flow in cardiovascular disorders. On the other side, flow (shear stress)-mediated outward remodelling (FMR), involved in collateral arteries growth in ischaemic diseases, allows revascularization. We hypothesized that the type 2 receptor (AT2R), described as...

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PMID: 27328880
DOI: 10.1093/cvr/cvw172

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