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Article

Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Dec 2014

Araújo E S S de, Vasques L R, Stabellini R, Krepischi A C V, Pereira L V

Abstract excerpt

DNA methylation is essential in X chromosome inactivation and genomic imprinting, maintaining repression of XIST in the active X chromosome and monoallelic repression of imprinted genes. Disruption of the DNA methyltransferase genes DNMT1 and DNMT3B in the HCT116 cell line (DKO cells) leads to global DNA hypomethylation and biallelic expression of the imprinted gene IGF2 but does not lead to reactivation of XIST...

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Identifiers

PMID: 25387668
PMCID: PMC4244667

Genes

IGF2
DNMT1
PEG10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line.PMID 25387668Read ↗

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