Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proliferating cell nuclear antigen (PCNA) is required for cell cycle-regulated silent chromatin on replicated and nonreplicated genes.

The Journal of biological chemistry - 5 Nov 2010

Miller Andrew, Chen Jiji, Takasuka Taichi E, Jacobi Jennifer L, Kaufman Paul D, Irudayaraj Joseph M K, Kirchmaier Ann L

Abstract excerpt

In Saccharomyces cerevisiae, silent chromatin is formed at HMR upon the passage through S phase, yet neither the initiation of DNA replication at silencers nor the passage of a replication fork through HMR is required for silencing. Paradoxically, mutations in the DNA replication processivity factor, POL30, disrupt silencing despite this lack of requirement for DNA replication in the establishment of silencing....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Antigens, Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Fungal

Share to Histone Acetyltransferases

Share to Molecular Chaperones

Share to Proliferating Cell Nuclear Antigen

Share to Ribonucleases

Share to S Phase

Source

Open in PubMed Open full text

Identifiers

PMID: 20813847
DOI: 10.1074/jbc.M110.166918
PMCID: PMC2966128

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proliferating cell nuclear antigen (PCNA) is required for cell cycle-regulated silent chromatin on replicated and nonreplicated genes.PMID 20813847Read ↗

Proliferating cell nuclear antigen and ASF1 modulate silent chromatin in Saccharomyces cerevisiae via lysine 56 on histone H3.Semantic proximity Read ↗

PCNA connects DNA replication to epigenetic inheritance in yeast.Semantic proximity Read ↗

A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cell cycle requirements in assembling silent chromatin in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mcm10 mediates the interaction between DNA replication and silencing machineries.Semantic proximity Read ↗

Impact of Homologous Recombination on Silent Chromatin in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in the DNA processivity factor POL30 predispose the FLO11 locus to epigenetic instability in S. cerevisiae.Semantic proximity Read ↗

In vivo analysis reveals that the interdomain region of the yeast proliferating cell nuclear antigen is important for DNA replication and DNA repair.Semantic proximity Read ↗

Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1.Semantic proximity Read ↗

Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.Semantic proximity Read ↗

DNA replication forks pause at silent origins near the HML locus in budding yeast.Semantic proximity Read ↗

Cell-cycle control of the establishment of mating-type silencing in S. cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.